Polacrilin Potassium also known as PP is an excipient used in pharmaceutical formulations. This excipient is not used in the majority of pharmaceutical industries because it is not a common excipient but it has many good properties and is used in pharmaceutical dosage forms.
Other Names
- Kyron
- Potassium Salt
What is Kyron?
- Kyron is Polacrilin Potassium and is an ion exchange resin.
- It is a partial potassium salt of a copolymer of methacrylic acid with divinylbenzene.
- In simple words Kyron is a brand name for polacrilin Potassium.
- It is a cross-linked derivative of polyacrylic polymer.
Role Of Polacrilin Potassium
- It is mainly used as disintegrant.
- It is used to Mask the taste.
- It is used to modify the taste.
- It is used to enhance drug stability.
- Improve dissolution.
- Enhance bioavailability.
- It is used in manufacturing of sustained release formulations.
- Give strength to the tablet.
- Prevent sticking to the dyes and punches.
Kyron as Disintegrant
- Kyron is used as a disintegrant in pharmaceutical formulations.
- Kyron shows disintegration mechanism by wicking mechanism.
- It gives good disintegration for many tablet formulations and is also very effective for hydrophobic formulations.
Concentration Used
It is used as a disintegrant in 2-10%.
Kyron as Taste Masking agent
- As we know kyron is an ion exchange resin so it is also used in pharmaceutical formulation to mask the bitter taste of drugs.
- When we use it as a taste masking agent for bitter drugs the bitter drugs are absorbed on ion exchange resin so when the drug passes through the oral cavity the bitterness is not feeled.
- It is also used as a taste masking agent in orodispersible tablets as we know that orodispersible tablets dissolve in mouth so taste masking using kyron is a good choice and it also aids in disintegration.
Examples
Most common examples of drugs for which kyron is used to mask taste is as follow,
- Azithromycin
- Amodiaquine Hcl
- Dextromethorphan
- Erythromycin
- Ondansetron Hcl
- Zinc Sulphate
- Ciprofloxacin Hcl
Also Read:
Difference between Validation & Calibration.
As Dissolution enhancer
It is also used to enhance bioavailability of anionic drugs or in other words it improves dissolution profile of drugs.
Grades of Kyron
Different grades of Kyron are as follow,
- Kyron T 104
- Kyron T 134
- Kyron T 114
- Kyron T 154
- Kyron T 123
- Kyron T 159
- Kyron T 314
Kyron T 114
- It is a derivative of methacrylic acid.
- It is a cross linked polymer.
- It is weakly acidic.
- It has a carboxylic acid functional group.
- Carboxylic acid functional group of kyron T 114 results in a taste masking property.
- It is specially used to mask the taste of beta lactam antibiotics.
- kyron T 114 has less than 5% moisture content.
- It has a porous nature due to crosslinking so is also used as a sustained release agent.
Kyron T 134
- It is a derivative of acrylic acid.
- It is a cross linked polymer.
- Kyron T 134 has k+ ionic form.
- It is a high purity polymer.
- It also has a carboxylic acid functional group.
- It is used as a taste masking agent.
- kyron T 134 has less than 10% moisture content.
Kyron T 154
- It is a derivative of styrene and divinylbenzene.
- It is a cross linked polymer.
- It has a sulfonic acid functional group.
- The sulfonic acid functional group gives it a taste masking property.
- It has a porous nature due to crosslinking so is also used as a sustained release agent.
Amount of potassium
When polacrilin potassium is dried at 105°C for 6 hours it contains not less than 20.6% and not more than 25.1 % potassium.
LOD
LOD or loss on drying means weight loss after drying so polacrin potassium is when dried at 105°C for 6 hours it loses not more than 10% of its weight.
Also Read:
Potency calculation of Active pharmaceutical Ingredient.
Solubility
Polacrin potassium is insoluble in water.
Incompatibility
Polacrin potassium is incompatible with oxidizing agents and amines.
Reference
- Handbook of pharmaceutical excipients.
- Practical Observations.
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