Calcium Phosphate dibasic dihydrate uses in tablets

Calcium phosphate dibasic dihydrate is used as an excipient in pharmaceutical products and it is also used in dietary supplements as a source of calcium.It is also called DCP or dibasic calcium phosphate. Dibasic calcium phosphate is an insoluble and inorganic excipient.

Main Uses:

• It is used as a tablet diluent.
• It is also used as a capsule diluent.

Other Uses:

• It is used in toothpaste.
• Used as a food additive.
• It is used in poultry feed.

Note

• Calcium phosphate dibasic dihydrate is non-hygroscopic and is stable, but some time on specific conditions it may lose water of crystallization.
• DCP needs a swelling type of disintegrant when used as diluent.

Grades Of DCP

It has two grades 

• Coarse grade
• Milled grade

Milled grades are used as a diluent  in wet granulation and dry granulation

The coarse grade is used as a diluent in dry granulation because it has good flow properties.

Properties

• Dibasic calcium phosphate dihydrate or
• DCP has good compaction properties.
• DCP coarse grade deform by a brittle fracture.
• Dibasic calcium phosphate dihydrate or DCP is abrasive

Incompatible

Dibasic calcium phosphate dihydrate is incompatible with following,

• Aspirin
• Ampicillin antibiotic
• Aspartame a sweetener
• Erythromycin antibiotic

DCP has an alkaline surface so it should not be used with alkaline pH-sensitive drugs.

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