What is Production?
All the activities involved in the manufacturing of a pharmaceutical product starting from receipt of raw materials to the completion of a finished product means, from Raw material Receipt to Finished product dispatch.
It contains the handling of manpower and recording of the manufacturing and the packing activity.
What is Batch Manufacturing Record(BMR)
BMR is a Document that provides a history of a batch mean how a product is manufactured step by step following written procedures.
It contains signs of qualified persons and operators involved in manufacturing.
What is Batch packaging Record (BPR)
Batch packaging record or BPR is the document that provides a history of batch packaging and in-process checks of Packaging.
Tablet is a solid dosage form prepared by a combination of API and Excipients by application of pressure.
What is API
API stands for Active pharmaceutical ingredient.
API is a substance that gives pharmacological effects.
What is ExcipientInert materials which do not give any pharmacological effect.
Classification of Excipients for Solid Dosage form
- Diluents
- Binders
- Disintegrants
- Glidents
- Lubricants
- Colourants
- Flavours
Tests for Tablet
- Weight variation
- Thickness
- Hardness
- Friability
- Disintegration
- Dissolution
- Assay
- Content uniformity
Also Read
Cleaning Validation In Pharmaceutical Industry
what are Defects of Tablet
- Capping
- Lamination
- Sticking
- Picking
- Weight Variation
What is Disintegration
The time needed for tablet or capsule to break down into particles which pass through # 10 mesh and no solid mass is left.
What is Disintegration Time of Capsules
30 Min.
Not more than 15 minutes.
Not more than 30 minutes.
Not more than 60 minutes.
What is the limit of friability
Not more than 1%
Also Read
Defects of Coating
- Sticking
- Colour variation
- Orange peel effect
- logo filling
- chipping
- Film cracking
Types of coating
- Film Coating
- Enteric Coating
- Sugar Coating
What is HVAC?
Heating Ventilation and Air conditioning
Functions Of HVAC
- Prevent cross-contamination
- Maintain Temperature
- Maintain Humidity
- Create Differential Pressure
- Maintain Air Changes
Types of capsules
- Hard Gelatin Capsule
- Soft Gelatin Capsule
- Starch
- Cellulose
- Gelatin
PVP k 30 or kollidon, povidone.
Why do we manufacture granules?
Granules are prepared for tablet compression because of the following main reasons.
- To enhance flow because powders flow is poor.
- To prevent weight variation.
- To reduce dusty environment because powders are dustier.
- To prevent segregation.
- To improve content uniformity.
- To improve compaction.
- Powders are elastic so tend to cap but granules are plastic so prevent tablet capping.
What is a rat hole?
Rathole is a powder flow defect in which powder adheres to the walls of compression machine hopper or blender walls and stops the flow against walls creating a hole in the middle. It results in weight variation and fragile tablets during compression.
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Add your interview questions in comment box to get answer in the post
Difference between GMP and cGMP
GMP is a system to ensure products are consistently produced and controlled according to quality standards. The “c” in cGMP stands for current which indicates that the most recent standards, technology, and methods are being applied to operations.
GMP is a system to ensure products are consistently produced and controlled according to quality standards. The “c” in cGMP stands for current which indicates that the most recent standards, technology, and methods are being applied to operations.
thanks
How to calculate sample size for 100mg
Why we used 70% sorbitol solution why not 100?
Great work you are doing may Allah bless you JazakAllah
Thanks
Great job sir
Thanks dear
What is deviation and change control?.
What are the limitations of disintegration test and dissolution test.
Difference bet GMP and CGMP with examples …
https://www.pharmainform.com/2021/01/good-manufacturing-practicegmpdifferenc.html
Thanks for sharing
It's v informative..keep it up
What is validation and types
Difference between validation and calibration
Validation is for process nd calibration is for instrument.
validation is a whole process that assures the quality and durability and make the things up to date,
while calibration is done for instrument to work properly.
Very informative Allah bless you sir
Then,whats the answer
Super
thanks
What are the defects of tablet granulation ??
very Informative
JAZAK ALLAH sir
Explain stability zones
why we used 3Molar KCl for pH meter not 2 or 1 m?
Asslamu alikum sir my question is what is the different between standars vessels and peak vessels